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Xiaofan Qiu Selected Research

Caspase 6

10/2020Compromised IGF signaling causes caspase-6 activation in Huntington disease.
1/2019Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.
1/2018Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli.
1/2017Palmitoylation of caspase-6 by HIP14 regulates its activation.
1/2016Laquinimod decreases Bax expression and reduces caspase-6 activation in neurons.
5/2015A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.
4/2015Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice.
2/2014p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.

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Xiaofan Qiu Research Topics

Disease

9Huntington Disease (Huntington's Disease)
10/2020 - 02/2014
4Neurodegenerative Diseases (Neurodegenerative Disease)
10/2020 - 04/2015
2Hypertrophy
04/2014 - 08/2013
1Disease Progression
01/2019
1Inflammation (Inflammations)
01/2018
1Multiple Sclerosis
01/2016
1Body Weight (Weight, Body)
04/2015
1Neoplasms (Cancer)
06/2011

Drug/Important Bio-Agent (IBA)

8Caspase 6IBA
10/2020 - 02/2014
4Proteins (Proteins, Gene)FDA Link
10/2020 - 04/2014
3polyglutamineIBA
10/2020 - 04/2015
2Isoproterenol (Isoprenaline)FDA LinkGeneric
04/2014 - 08/2013
1CaspasesIBA
01/2018
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2018
1Peptide Hydrolases (Proteases)FDA Link
01/2018
1laquinimodIBA
01/2016
1Insulin-Like Growth Factor I (IGF-1)IBA
04/2015
1Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
08/2013
1ErbB Receptors (EGF Receptor)IBA
06/2011
1Epidermal Growth Factor (EGF)IBA
06/2011
1Mitogen-Activated Protein KinasesIBA
06/2011